CELL AND GENE THERAPY INSIGHTS

March 2026 Issue

Volume 12 Issue 2

Cell and Gene Therapy Insights Volume 12 Issue 2
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Featuring

Issue Spotlight: Gene therapy analytics/CMC
Supply Chain focus: Raw and Starting Materials
Vectors focus: Upstream Processing 2026
Other articles
Webinars

SPOTLIGHT

Gene therapy analytics/CMC
Srivatsan Ramesh
Guest Editor:
Srivatsan Ramesh, Scientist at BridgeBio

Foreword

Engineering confidence in the next era of AAV-based gene therapy

Engineering confidence in the next era of AAV-based gene therapy

Srivatsan Ramesh
27 March
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Research Article

Tailored analytical strategies for AAV aggregation: purpose‑driven method selection for enhanced product development

Tailored analytical strategies for AAV aggregation: purpose‑driven method selection for enhanced product development

Y Zhao, L Wang, J S Reeves et al.
31 March
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Expert Insight

New analytical method for rAAV titer and empty/full ratio determination in cell lysate and conditioned medium

New analytical method for rAAV titer and empty/full ratio determination in cell lysate and conditioned medium

Yuki Yamaguchi, Susumu Uchiyama
31 March
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Viewpoint

Unraveling the analytical bottlenecks in AAV characterization: the transformative promise of NGS

Unraveling the analytical bottlenecks in AAV characterization: the transformative promise of NGS

Prateek Tripathi
6 March
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From dose quantity to dose quality: elevating rAAV genome integrity as a CMC attribute

From dose quantity to dose quality: elevating rAAV genome integrity as a CMC attribute

XuShan Wang, Sarah M Richer, Beverly A Heinz
3 March
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Next-generation strategies for managing AAV pre-existing immunity: beyond standard companion diagnostics

Next-generation strategies for managing AAV pre-existing immunity: beyond standard companion diagnostics

Katherine Block
24 February
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Supply Chain FOCUS

Raw and Starting Materials

Viewpoint

Building confidence in cell and gene therapy: USP’s role in an evolving therapeutic frontier

Building confidence in cell and gene therapy: USP’s role in an evolving therapeutic frontier

Fouad Atouf
17 March
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Vectors FOCUS

Upstream Processing 2026

Interview

Advancing AAV manufacturing through platform design and process understanding

Advancing AAV manufacturing through platform design and process understanding

Pranav Joshi
31 March
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articles

Editorial

Editor’s picks: exploring in vivo cell and gene therapies

Editor’s picks: exploring in vivo cell and gene therapies

Abigail Pinchbeck
16 March
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Innovator Insight

Choosing a biomanufacturing service organization: from the BSO perspective

Choosing a biomanufacturing service organization: from the BSO perspective

R Thevi Guntnur, R Rendon III, J Higdon et al.
26 March
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Industry Insights

Industry Insights: Regulatory dynamics and clinical progress in early 2026

Industry Insights: Regulatory dynamics and clinical progress in early 2026

Abigail Pinchbeck
8 April
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Webinars