Uncovering CAR-T and CAR-NK cell potency using multi-analyte profiling

Tuesday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET

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Uncovering CAR-T and CAR-NK cell potency using multi-analyte profiling

Demonstrating effector cell potency remains a critical requirement for CAR-T and CAR-NK cell therapy development, yet reliance on single-analyte readouts such as IFN-γ can limit functional insight. This webinar presents a data-driven approach that integrates multiplex screening with sensitive quantification to enable deeper characterization of immune cell potency.

Presenting data based on CD19-CAR-T and CD19-CAR-NK cells from multiple donors, the session will show how targeted multi-analyte assays support more representative potency assessment, aligned with evolving regulatory expectations.

Key takeaways

Review comparative secretion profiling data identifying 29 differentially secreted analytes in CD19-CAR-T cells and 13 in CD19-CAR-NK cells from an initial 123-analyte screen
Learn how multi-analyte protein biomarkers provide a more representative measure of effector cell potency than IFN-γ alone
See data from a streamlined approach that moves from broad discovery and effector cell characterization to tailored, multi-analyte potency assays for immunotherapies
Understand how this approach enables more comprehensive characterization of immune cell function to better define potency and therapeutic relevance

Register now to gain practical insight into multi-analyte potency assays that support deeper functional characterization of CAR-T and CAR-NK cell therapies.

Jessica Fiege

Supervisor, Customer Applications, Immune Cell Therapy at Bio-Techne

Jessica Fiege is a distinguished Scientist specializing in Cell and Gene Therapy. Earning her Ph.D. in Immunology from the University of Minnesota, her research focused on T cell activation and differentiation. During her post-doctoral work, she conducted in-depth research on innate and adaptive immune cell responses to viral infections. At Bio-Techne, Jessica is a Supervisor on the Immune Cell Therapy team, driving improvements in CAR-T immunotherapy manufacturing with a focus on high-quality and cost-effective treatments.

Valeriu Bortnov

Senior Scientist at Bio-Techne

Valeriu Bortnov is a Senior Scientist at Bio-Techne, where he leads the development of multiplex Luminex immunoassays for protein analyte panels. In his current role, Valeriu oversees projects from conceptualization through validation and product launch, driving innovation in immunoassay design and optimization. He earned his PhD in Biochemistry from the University of Wisconsin–Madison, where his research focused on protein expression, purification, and structural characterization using advanced biochemical and biophysical techniques. His expertise spans immunoassay development and protein biochemistry, supporting applications in biomarker discovery and therapeutic research.

In 32 Days

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