Accelerating lung-targeted LNP development with curated lipid libraries and accessible characterization workflows

Thursday 09:00 PDT / 12:00 EDT / 16:00 GMT / 17:00 CET

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Accelerating lung-targeted LNP development with curated lipid libraries and accessible characterization workflows

Delivering nucleic acids to specific organs and cell types is a key challenge in developing future therapeutics, from rare genetic diseases to cancer. Lipid nanoparticles (LNPs) represent a tunable and modular platform for addressing many of these delivery challenges. However, screening LNPs for specific targeting and transfection efficiency can be difficult due to the large number of possible components and formulation combinations.

To simplify early-stage screening, Cayman Chemical has developed screening-ready reagent sets composed of lipids selected for their reported organ- and cell-targeting properties. Using Unchained Labs' Sunshine™ and Stunner™ instruments, published formulations from the LipidLaunch™ Lung Screening Set were evaluated, and key biophysical properties were assessed. This yields valuable insight before going to the next stage of assessing in vitro cytotoxicity and transfection efficiency.

By combining curated reagent sets with accessible analytical tools, researchers can rapidly generate and evaluate diverse LNP formulations, simplifying the development of targeted delivery strategies for lung-directed applications. Attendees will gain practical insights into leveraging curated lipid libraries and streamlined characterization workflows to efficiently identify and assess promising LNP formulations.

Julie Rumble, PhD

Director of Immunology and Cell Biology at Cayman Chemical

Julie Rumble is the Director of Immunology and Cell Biology at Cayman Chemical. After completing her PhD in Immunology at the University of Michigan and a postdoctoral fellowship in NeuroImmunology with Dr Benjamin Segal, she moved to Cayman Chemical to work in assay development. Since then, she has worked to expand the Immunology Services offerings for Cayman and focused on immunopeptidome analysis, lipid nanoparticle formulation and testing and other immunological analyses.

Ben Knappett, PhD

Sr. Product Manager, Sunny Suite at Unchained Labs

Ben Knappett is Senior Product Manager for the Sunny Suite, Unchained Labs’ automated microfluidic nanoparticle synthesis instruments, used primarily for LNP encapsulation in drug delivery, vaccines, and gene therapy applications. Ben received his MChem degree from Durham University, and completed a PhD in nanoparticle synthesis and characterization at the University of Cambridge. Ben previously worked for Particle Works as Head of Science and Applications, playing a key role in the development and commercialization of the instruments that now make up the Sunny Suite.

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