Switch out the PEG - optimization of polysarcosine lipid nanoparticles for mRNA delivery

Ben Knappett is Senior Product Manager for the Sunny Suite, Unchained Labs’ automated microfluidic nanoparticle synthesis instruments, used primarily for LNP encapsulation in drug delivery, vaccines, and gene therapy applications. Ben received his MChem degree from Durham University, and completed a PhD in nanoparticle synthesis and characterization at the University of Cambridge. Ben previously worked for Particle Works as Head of Science and Applications, playing a key role in the development and commercialization of the instruments that now make up the Sunny Suite.

Fabian Link is a PhD student at the Institute of Pharmaceutical Technology at LMU Munich in the group of Prof. Olivia Merkel and a member of the CPC-M site. With a background in chemistry, his research focuses on the development of lipid nanoparticles (LNPs) for RNA delivery. His work combines machine learning, statistical modeling, and experimental design with wet-lab formulation and biological evaluation to reduce the experimental complexity of LNP development. By integrating data-driven approaches with hands-on experimentation, he aims to accelerate the rational design of RNA delivery systems for future nanomedicine applications.