A mechanistic perspective of RNA‑LNP instability and characterization toolbox

“...chemically engineering lipids and leveraging AI/ML guided design can offer promises in generating LNP libraries with lower RNA‑adduct formation.”

LNPs are proven to be effective nanocarriers for delivering nucleic acid in vivo. The US FDA approval of multiple LNP‑based drug products catalyzed multiple clinical studies across disease indications covering various RNA modalities. However, the stability of LNPs has been a long‑lasting challenge. This Viewpoint article talks about reported observations of RNA‑LNP instability, methods to quantify, and ways to improve the drug product profile.

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