Decoding mRNA stability: from endogenous decay pathways to therapeutic design

“...we need further work to expand our knowledge on mRNA‑protein interactomes across different tissue types or specific disease contexts...”

Jokūbas Leikauskas, Editor, Nucleic Acid Insights , speaks to Khalid SA Khabar, Research Group Leader, King Faisal Specialist Hospital and Research Center, about how fundamental research into endogenous mRNA decay pathways, including AU‑rich elements, RNA‑binding proteins, and innate immune interactions, can inform the design and stabilization of therapeutic mRNAs.

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