Turbocharging pDNA production: a case study on optimization through novel technologies

Tuesday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST

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Turbocharging pDNA production: a case study on optimization through novel technologies

Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format.

This webinar will showcase a real-life case study from Forge Biologics in collaboration with Repligen, highlighting how to optimize tangential flow filtration (TFF) and chromatography to achieve a 300% reduction in pDNA processing time while enhancing RNA removal and maintaining high supercoiled DNA levels.

The speakers will provide insights into key process parameters, including the impact of molecular weight cutoff and shear rate purification. Additionally, they will discuss practical strategies for scale-up to larger manufacturing environments.

Attend this webinar to:

Learn how optimizing TFF and chromatography can significantly reduce pDNA processing time by 300%, improving overall manufacturing efficiency
Understand the impact of molecular weight cutoff and shear rate on pDNA, and explore strategies to improve RNA removal while maintaining high supercoiled DNA levels
Gain insights into best practices for scaling up pDNA production to ensure a smooth transition to larger manufacturing environments

Xiangming Gu

Scientist II, Plasmid Process Development - Downstream at Forge Biologics

Dr. Xiangming has been a pivotal figure in Plasmid Process Development at Forge Biologics since 2023. Specializing in downstream process optimization and purification, his expertise in chromatography and tangential flow filtration has led to significant advancements in plasmid DNA processes. At Forge Biologics, Dr. Xiangming is known for his dedication to achieving impactful results and fostering collaboration within the biopharmaceutical industry.

Lucas Smith

Senior Product Manager, TFF Systems at Repligen

With decades of application engineering experience in biotech and medical device industries, Lucas Smith has consulted with companies globally on equipment design with a focus on bioreactors, mixers, and TFF systems. As product manager he plays a critical role in aiding the development and delivery of innovative TFF solutions by Repligen.

in 7

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