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Isolating CD4+ and CD8+ T cell subsets is critical for controlling the ratio within the final drug product. It also has impacts downstream steps such as cryopreservation after isolation. Achieving younger, less differentiated T cells is important for optimizing clinical outcomes. With this in mind, Thermo Fisher Scientific is releasing a first-of-its-kind platform technology that enables isolation of CD4+ and CD8+ T cells with a key differentiator: an active release mechanism for clinical trial or commercial manufacturing.
The Gibco™ CTS™ Detachable Dynabeads™ CD4 Kit and the Gibco™ CTS™ Detachable Dynabeads™ CD8 Kit each possesses a proprietary active release mechanism that enables active release of Dynabeads from the cells at any time in the process while maintaining high cell yield. Conjugated to highly specific, single-domain VHH antibodies that target specific clusters of differentiation markers, the performance exhibits consistent and optimal isolation and purity of target T cell populations while addressing the biological variability that cell therapy manufacturers are facing.