Smarter lentiviral manufacturing for CAR-T: increased productivity meets smart purification

Wednesday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET

Sponsor

Smarter lentiviral manufacturing for CAR-T: increased productivity meets smart purification

This webinar explores integrated strategies for optimizing lentivirus manufacturing, combining improved upstream efficiency with advanced downstream purification techniques. Attendees will gain insights from real-world data showing significant improvements in upstream yield, transduction efficiency, downstream recovery and process scalability, without disrupting existing platforms. Discover an integrated solution that can significantly boost output, shorten timelines, and reduce costs all in one comprehensive approach.

Rapid optimization of LVV production

Attendees will explore how High-Throughput Virology (HTV™) and design of experiments (DoE) approaches can be applied to optimize upstream lentiviral vector (LVV) production. This approach has rapidly identified small-molecule media additives that deliver more than 2× functional LVV yield in adherent formats and over 3× in suspension systems.

Innovative approaches for gentler purification

Attendees will learn how Tozaro’s Smart Polymer™ platform combines advanced polymer chemistry and computational design to develop affinity ligands that enable gentle capture and release of LVV. Case study data demonstrate effective removal of host cell proteins (HCPs) and residual DNA, enabling scalable purification while preserving vector quality.

Boosting productivity without process disruption

The webinar presents case studies on Virica’s VSE™-powered CellVantage™ lentivirus enhancers demonstrating up to a 4× increase in lentivirus production and a 3× improvement in transduction efficiency, without altering existing manufacturing platforms.

Integrated strategies for scalable manufacturing

Participants will gain insight into a holistic process that combines upstream and downstream improvements to enhance scalability, reduce host cell protein and residual DNA, and increase batch yield.

Practical upstream and downstream levers that drive higher productivity and lower costs in lentiviral vector manufacturing
Innovative approach to shorten development time by focusing on vital changes that increase productivity, accelerate milestones, and cut costs
How to maintain platform compatibility so improvements fit into existing adherent and suspension systems without re-engineering

Jean-Simon Diallo

CEO and Scientific Founder at Virica Biotech

Dr. Jean-Simon Diallo, Ph.D, is a scientist with broad expertise in biochemistry, molecular biology, cancer therapeutics and viral immunology. Dr. Diallo is an internationally recognized expert in oncolytic virotherapy and was seminal in the discovery of Viral Sensitizers and their development for virus manufacturing and cancer therapy applications in combination with oncolytic viruses.

Jason Slingby

CEO at Tozaro

Dr. Jason Slingsby is a commercial leader in the cell & gene therapy sector and was previously Chief Business & Corporate Development Officer at Oxford Biomedica, a leading viral vector CDMO with expertise in lentiviral vectors and AAV. He has negotiated multiple high value license and supply agreements with big Pharma and biotechs in the rapidly emerging CAR-T field and has commercialised multiple gene therapy technologies to drive revenue growth.

You have registered for this webinar