In the making: lessons from 50 years in vaccine development

“Each step forward depends not only on innovation, but on the discipline to test and question what we think we already know.”

Over a career spanning five decades, Jerry Sadoff has helped shape some of the most significant advances in modern vaccinology, playing a key role in bringing no less than 14 licensed vaccines to market. Here, he reflects on the projects that shaped his approach to vaccine innovation and the principles that have guided his work: the balance between risk and responsibility, the importance of ethical clarity in scientific decision-making, and the persistence needed to turn long-held hypotheses into clinical reality.

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