Producing engineered extracellular vesicles with a platform approach

Thursday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET

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Producing engineered extracellular vesicles with a platform approach

Extracellular Vesicles (EVs), including exosomes, are emerging as promising natural nano-scale platforms for delivering gene therapies, nucleic acids, proteins, and small molecules. However, precision EV engineering has been challenging to date, and such technologies have been inaccessible to the broader community due to technical complexities.

In this webinar, we'll discuss materials and methods to enable the expression of biomolecules on EVs. Data will be shared for using protein scaffolds such as PTGFRN and BASP-1 that are clinically proven to effectively load therapeutic proteins on the surface or lumen of EVs. Chemical linkers were developed to link nucleic acids or small molecules to the EV membrane while preserving their bioactivity and potency. We will also present case study clinical-stage data and further platform developments.

Learn why EVs including exosomes are a promising modality to deliver therapeutic payload with an excellent safety profile
Find out how novel linking and loading technologies can enable the precision engineering of EVs, through case study examples and clinical stage data
See clinical data for therapeutics that have completed Phase 1 studies within oncology applications, including exoSTING™, exoASO-STAT6™, and exoIL-12™
Platforms and related clinical assets described here were acquired from Codiak Biosciences and are now available to pharma, biotech and academic communities

Vijetha Bhat

CGT Technical Expert at Lonza Licensing

Vijetha Bhat is a subject matter expert working within Licensing in Lonza’s Cell and Gene Technologies space. She has nearly 15 years of experience in the biopharma industry. Vijetha started her scientific career at Lonza in 2017 and has since contributed to a variety of projects focusing on developing platforms and analytics for viral vector production. She currently supports with providing in-depth technical direction to users working with Lonza’s Cell and Gene expression platforms.

Vijetha has a background in biotechnology from India. She graduated from Rice University in Houston with a degree in Bioengineering. Prior to joining Lonza, she worked at Nanospectra Biosciences, an early-stage medical device company, developing nanotechnology-based therapies for oncology applications.

in 25

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