Complexity be damned: the need to better use biology to achieve more impactful cell therapies

Cell & Gene Therapy Insights 2020; 6(1), 41-46


Published: 3 February 2020
Nancy L Parenteau

Biological complexity is both a benefit and a bane of cell therapy. An astute partnership with nature is required to achieve a reliable clinical outcome from cell therapy. To accomplish it, we must dig deep enough to acquire knowledge crucial to translation, while maintaining a perspective that will prevent misdirection. Not every bit of information will be of equal importance, yet we can’t skip over or miss what could be pivotal. Dealing with the biological complexity surrounding cell therapy may seem like a risky balancing act. However, luck favors the prepared, and there are practices we can employ to reduce translational risk and form a clinically impactful collaboration between science and nature.