Society is not ready to bet on embryo editing

“We argue the case against the use of HHGE for at least the next 10 years for three central reasons: lack of medical need, unproven safety, and significant unresolved ethical and governance concerns”

Multiple entities have argued against the use of heritable human germline editing (HHGE) for at least the next ten years due to a lack of medical necessity, unproven safety, and unresolved ethical and societal concerns. The safety of HHGE remains unclear, with risks such as mosaicism and unintended genetic changes that could impact future generations.  Ethical and societal issues, including the potential for eugenics and increased inequity, have not been adequately addressed through inclusive public dialogue. We reiterate the call for a moratorium on HHGE until robust ethical, legal, and global governance frameworks are established and society reaches a consensus on its use.

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