Breakthroughs, challenges and the road ahead: immune challenges in AAV gene therapy

“When you see the success of certain gene therapies and how well patients are doing, it is remarkable. I hope that we will have more AAV and CRISPR therapies going forward that are truly life‑changing.”

Wil Rich, Editor, Cell and Gene Therapy Insights, speaks with Allison Keeler, Assistant Professor in the department of Genetic and Cellular Medicine at the University of Massachusetts Chan Medical School, about the key immune barriers facing AAV‑based gene therapies, the promise of CAR‑T regulatory cells as immunomodulatory tools, and the challenges of translating animal model findings to the clinic.

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