Optimizing upstream cell culture with rapid at-line and in-line analytics

Cell therapy manufacturing faces significant variability in materials and processes, but the use of advanced analytical tools can help identify and control these sources of variation—improving cell culture consistency, increasing yield, and ensuring reliable product quality. This article discusses the use of process analytical technology (PAT) tools to address these challenges by enabling real-time monitoring of critical process parameters including amino acids, glucose, lactate, and biomass. Additionally, case studies from Ultragenyx, Emory University, and Resilience demonstrate how these technologies streamline analytics, enhance process understanding, improve productivity, and reduce costs.

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