Protein characterization using variable pathlength spectroscopy: high- & low-concentration methods

Vaccine Insights 2023; 2(11), 447–455

DOI: 10.18609/vac/2023.60

Published: 5 January
Innovator Insight
Paul Mania, Nigel Herbert

The potential to tailor bioanalytical methods to specific biologic therapeutic products is critical to effectively meet regulatory CMC expectations. This article describes the use of variable pathlength technology for protein concentration measurement, with a particular focus on exploring low- and high-concentration methodologies.