Unravelling immunogenicity induced by Cas9 in gene therapy: a comprehensive commentary of current understanding and implications

Cell & Gene Therapy Insights 2023; 9(9), 1309–1318

DOI: 10.18609/cgti.2023.168

Published: 8 November
Anna Lina Cavallo

Gene therapy holds immense potential for treating genetic disorders by manipulating the patient’s genetic material. The application of CRISPR-Cas9, a revolutionary gene editing system, has paved the way for precise and efficient genetic modifications. However, understanding the Immunogenicity induced by Cas9 is crucial for optimizing its use in gene therapy. This comprehensive commentary aims to explore the current knowledge on Immunogenicity associated with Cas9 in the context of gene therapy. By elucidating the immunological responses triggered by Cas9, this work seeks to enhance our understanding and address potential implications for successful clinical implementation.