The supporting role of plasmids in gene & cell therapy

The biopharmaceutical relevance of producing plasmid DNA at large scale has increased steadily over the years due to the development of a growing number of direct and indirect applications. Be it as biological drugs or as starting materials, plasmids are pervasive across the gene and cell therapy industry of today. With hundreds of biopharmaceutical companies using plasmids in the clinical development of their products, plasmid manufacturing is starting to emerge as a key bottleneck. This commentary provides an overview of the uses of plasmids, discusses manufacturing challenges, and hints at what the future may bring. 

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