Vol 9 Issue 9

CELL AND GENE THERAPY INSIGHTS

November 2023 Issue

Vol 9 Issue 9

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Featuring

Issue Spotlight: Fulfilling the potential of gene editing: at the tipping point
Downstream Processing
Other articles
Webinars

SPOTLIGHT

Fulfilling the potential of gene editing: at the tipping point
Claudio Mussolino
Guest Editor:
Claudio Mussolino, Group Leader, Genome and Epigenome Engineering at University of Freiburg

Expert Insight

Considerations for development of gene-edited PSC-based therapies

Considerations for development of gene-edited PSC-based therapies

Brent Morse, Amanda Mack
14 November
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‘Soft’ genome editing using CRISPR nickases as a potential source of safer cell products

‘Soft’ genome editing using CRISPR nickases as a potential source of safer cell products

Zhen Li, Manuel Goncalves
20 October
Read

Commentary

An update on prime editing: recent advances and applications

An update on prime editing: recent advances and applications

Karl Petri, Julian Grünewald
23 November
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Unravelling immunogenicity induced by Cas9 in gene therapy: a comprehensive commentary of current understanding and implications

Unravelling immunogenicity induced by Cas9 in gene therapy: a comprehensive commentary of current understanding and implications

Anna Lina Cavallo
8 November
Read

Interview

Advancing multiplex base editing into the clinic

Advancing multiplex base editing into the clinic

Gopi Shanker
10 November
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Exploring the convergence of gene editing and RNAi in iPSC-derived allogeneic cell therapy

Exploring the convergence of gene editing and RNAi in iPSC-derived allogeneic cell therapy

Vlad Seitan
8 November
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Developing a multiplex gene editing approach targeting viral infection

Developing a multiplex gene editing approach targeting viral infection

TJ Cradick
8 November
Read
Bringing the Sleeping Beauty transposon system to the clinic

Bringing the Sleeping Beauty transposon system to the clinic

Zoltán Ivics
18 October
Read

Vectors FOCUS

Downstream Processing

Interview

Navigating lentiviral vector downstream bioprocessing: an engineering perspective

Navigating lentiviral vector downstream bioprocessing: an engineering perspective

Andrea Rayat
5 October
Read

Innovator Insight

Considerations for affinity capture in an AAV platform downstream process

Considerations for affinity capture in an AAV platform downstream process

Jett Appel
22 November
Read
A scalable single-use two-step plasmid purification process

A scalable single-use two-step plasmid purification process

P Guterstam, H Blom, S Aberg et al.
1 November
Read

Disruptive bench-scale purification of lentivirus using affinity-liquid phase separation technology

Disruptive bench-scale purification of lentivirus using affinity-liquid phase separation technology

N Votaw, M Callander, T Broer et al.
1 November
Read

Journal articles

Innovator Insight

Exploring & overcoming the challenges of cell & gene-modified cell therapy CMC

Exploring & overcoming the challenges of cell & gene-modified cell therapy CMC

K Doucette, J Sable, L Bellot
18 October
Read
Establishing the standards of operational excellence to manufacture commercial cell therapies

Establishing the standards of operational excellence to manufacture commercial cell therapies

Melanie Mansbach, Hui Zheng
25 October
Read
AAV & lentiviral vector titer determination: past, present, & future

AAV & lentiviral vector titer determination: past, present, & future

M White, J Bechill, P Wang
1 November
Read
mRNA fragmentation and quality assessment using ion pair reverse-phase analytics

mRNA fragmentation and quality assessment using ion pair reverse-phase analytics

A Ferjančič Budihna, A Martinčič Celjar, S Lebar et al.
1 November
Read
Strategies to accelerate AAV chromatography process development

Strategies to accelerate AAV chromatography process development

Kelley Kearns
8 November
Read

Commentary

A new era in medicine: unraveling the evolution and future of gene therapy

A new era in medicine: unraveling the evolution and future of gene therapy

M Tanaka-Wakefield, J Ark, Y Gambhir et al.
25 October
Read

Interview

Building with the patient in mind: designing a state-of-the-art facility for viral vector manufacturing

Building with the patient in mind: designing a state-of-the-art facility for viral vector manufacturing

Louis-Marie De Montgrand, Morad El Gueddari
11 October
Read

Podcast

Can AAV continue to deliver the promise of gene therapy?

Can AAV continue to deliver the promise of gene therapy?

Ratish Krishnan, Elie Hanania
14 September
Listen

Conference Insight

Current trends in ATMPs

Current trends in ATMPs

Helena Strigard, Jonathan Royce
28 September
Read

FastFacts

HEK293 suspension culture in stirred 3D-systems for gene therapy development

HEK293 suspension culture in stirred 3D-systems for gene therapy development

Jorge Escobar
14 November
Read
Improving genetic engineering of adoptive cell therapies by a novel culture media supplement

Improving genetic engineering of adoptive cell therapies by a novel culture media supplement

D Pleitez, T Jerbi, M Safford et al.
18 October
Read

Viewpoint

Designing cell therapy analytics for future success

Designing cell therapy analytics for future success

Raymond Luke
21 September
Read

EBook

Trends and Innovation in Lentiviral Vector Processing

Trends and Innovation in Lentiviral Vector Processing

31 October
Read

Webinars