Vol 9 Issue 5

CELL AND GENE THERAPY INSIGHTS

June 2023 Issue

Vol 9 Issue 5

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Featuring

Issue Spotlight: Gene delivery platform evolution part 2: non-viral
Upstream processing
Other articles
Webinars

SPOTLIGHT

Gene delivery platform evolution part 2: non-viral
Lynn Zechiedrich
Guest Editor:
Lynn Zechiedrich, Kyle & Josephine Morrow Chair & Professor in Molecular Virology & Microbiology at Baylor College of Medicine

Foreword

Gene delivery platform evolution part 2: non-viral—Foreword

Gene delivery platform evolution part 2: non-viral—Foreword

Lynn Zechiedrich
5 August
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Expert Insight

The supporting role of plasmids in gene & cell therapy

The supporting role of plasmids in gene & cell therapy

Duarte Prazeres
6 July
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Interview

Exploring current shortfalls and potential improvements for non-viral gene delivery in cystic fibrosis

Exploring current shortfalls and potential improvements for non-viral gene delivery in cystic fibrosis

Uta Griesenbach
5 August
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Exploring the application of doggybone DNA to facilitate non-viral gene therapy delivery to hemophilia patients

Exploring the application of doggybone DNA to facilitate non-viral gene therapy delivery to hemophilia patients

Carol H Miao
20 July
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Developing non-viral delivery & cell engineering technologies for <em>ex vivo</em> T cell immunotherapies

Developing non-viral delivery & cell engineering technologies for ex vivo T cell immunotherapies

Julie Shi, Nirveek Bhattacharjee
30 June
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Expanding the potential of <em>in vivo</em> cell therapy with tLNP-RNAs (targeted lipid nanoparticle-RNA)

Expanding the potential of in vivo cell therapy with tLNP-RNAs (targeted lipid nanoparticle-RNA)

Adrian Bot
28 June
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Podcast

Non-viral methods for <em>ex vivo</em> cell & gene therapy: is the future non-viral?

Non-viral methods for ex vivo cell & gene therapy: is the future non-viral?

Valeria Annibaldi, Andrea Toell
1 August
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FastFacts

Reducing risk for cell therapy manufacturing with a battle-tested electroporation platform

Reducing risk for cell therapy manufacturing with a battle-tested electroporation platform

Andrew Mancini
25 August
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Addressing purification challenges: biological pipeline diversity and smaller manufacturing scales

Addressing purification challenges: biological pipeline diversity and smaller manufacturing scales

Sushma Nayak Teichert
12 July
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Vectors FOCUS

Upstream processing

FastFacts

A large-scale lentivirus manufacturing platform to accelerate time to clinic

A large-scale lentivirus manufacturing platform to accelerate time to clinic

Brian Mullan
3 June
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Innovator Insight

Environmental monitoring: optimizing microbial control in cell & gene therapy workflows

Environmental monitoring: optimizing microbial control in cell & gene therapy workflows

Nico Chow
20 June
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Research Article

Can novel bioreactors improve the cost of goods of viral vectors?

Can novel bioreactors improve the cost of goods of viral vectors?

C Stamatis, A Chatel, S Farid
20 June
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Review

AAV production by transient transfection: strategies & challenges

AAV production by transient transfection: strategies & challenges

Amanda Bretti, Stephanie Doong
6 July
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Journal articles

Research Article

Validation of mRNA concentration determination by slope spectroscopy technology: a matrixed approach

Validation of mRNA concentration determination by slope spectroscopy technology: a matrixed approach

T Alvine, N Unsinn, J Long et al.
14 June
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Expert Insight

A guided demonstration of the Counting Method Evaluation Tool (COMET) for implementing the ISO 20391-2 Cell Counting standard

A guided demonstration of the Counting Method Evaluation Tool (COMET) for implementing the ISO 20391-2 Cell Counting standard

L Pierce, D Newton, S Lund et al.
21 June
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Innovator Insight

Analyzing full & empty AAV capsid ratio in less than 5 minutes

Analyzing full & empty AAV capsid ratio in less than 5 minutes

Åsa Hagner McWhirter
6 July
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Podcast

Investing long-term in the cell & gene therapies of the future

Investing long-term in the cell & gene therapies of the future

Geeta Vemuri
29 March
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FastFacts

Efficient, scalable purification of VSV-G lentivirus by novel affinity chromatography

Efficient, scalable purification of VSV-G lentivirus by novel affinity chromatography

Frank Detmers
7 June
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An optimized & streamlined approach for upstream & downstream lentiviral production

An optimized & streamlined approach for upstream & downstream lentiviral production

Gregory Piscitello, Paul Turiano
11 July
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Webinars