Tools, trends, and technologies: analytical developments in ADCs

"Using the right analytical tools to support developability and manufacturability studies early on is essential to ensure that the right format reaches CMC development."

The structural complexity of modern ADCs, such as encompassing diverse linker–payload combinations, site‑specific conjugation strategies, and bispecific formats, demands analytical science that is both highly sophisticated and strategically deployed from the earliest stages of development.

Bioconjugate Insights convened a panel of leading experts – Wei‑Han Lee (TechOp Lead and Senior Director, OBI Pharma), Luying Yang (Senior Scientist and Analytics Group Lead, Zymeworks), and Eef Dirksen (Director of Analytical Development and Quality Control, Byondis) – to discuss the most pressing analytical challenges facing the ADC field, from discovery through to commercial manufacturing, and the emerging tools and approaches that are shaping the future of the discipline.

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