Reengineering membranes for the RNA era: overcoming diffusion, fouling, and scale-up barriers

“Ultimately, success will depend on robust standardization of process control and quality assurance across the industry, ensuring reproducibility and regulatory confidence as these systems move toward broader adoption.”

Ashling Cannon (Editor, BioInsights) speaks to Georges Belfort (Institute Professor of Chemical and Biological Engineering, Rensselaer Polytechnic Institute) about how his work in transport phenomena and membrane science is being applied to the manufacturing and purification of mRNA-LNP vaccines. They discuss how membrane-based systems outperform diffusion-limited chromatography for large biomolecules, strategies to reduce fouling and improve selectivity, and new insights into polymer microstructure and convective flow. Belfort also shares his perspective on designing low-cost, scalable membrane systems for global vaccine access and the need for a standardized RNA platform manufacturing process.

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