Accelerating AAV process development with high-throughput strategies

Tuesday 09:00 PDT / 12:00 EDT / 16:00 GMT / 17:00 CET

Sponsor

Accelerating AAV process development with high-throughput strategies

Live30 webinars pack the latest innovations and applications into a data-rich 30-minute session.

Gene therapy is rapidly advancing, yet rapid screening of optimal AAV viral vectors remains a key challenge. This is due to the time required for downstream purification and analytics, particularly the separation of the desired product from process- and product-related impurities.

This webinar introduces a novel high-throughput process and analytical development (HTPAD) platform designed to address these challenges by integrating Quality by Design (QbD) principles, automated purification, and at-line analytics. You will also learn about practical solutions that can help reduce time and cost while improving product consistency in AAV vector development.

Attend this webinar to discover:

How to conduct 100+ purification runs per week, thus streamlining your AAV process development
Strategies to integrate parallelized anion exchange (AEX) chromatography with at-line analytics for full capsid enrichment and rapid method screening
Data demonstrating scalability of a small-scale platform for efficient AAV candidate selection and process optimization across multiple serotypes

Dan Matuszek

Downstream Process Development Scientist at Thermo Fisher Scientific

Dan Matuszek specializes in viral vector purification with a focus on adeno-associated virus (AAV), herpes simplex virus (HSV), and adenovirus. He leads downstream projects spanning early- to late-stage process development for chromatography, tangential flow filtration, and normal flow filtration, applying various methods to optimize process performance. Prior to joining Thermo Fisher in 2024, Dan spent several years at MassBiologics, where he advanced AAV purification platforms and served as a subject-matter expert supporting an EMA-licensed gene therapy product.

You have registered for this webinar