Accelerating AAV process development with high-throughput strategies

Accelerating process development is essential for advancing viral vector manufacturing and enabling broader access to gene therapies. Advanced approaches, such as high-throughput process and analytical development (HTPAD), can provide a powerful framework to achieve this by combining automated experimentation with integrated analytics. Through parallelized chromatography screening and data-driven optimization, HTPAD compresses downstream development timelines, enhances scalability, and reduces costs. This article showcases case studies demonstrating its effectiveness in refining viral vector purification strategies, improving process robustness, and offering adaptable solutions applicable across multiple AAV serotypes.

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