Cryo-processed leukapheresis using an automated closed system: a high-quality starting material for autologous and allogeneic CAR-T cell therapy manufacturing

Cell & Gene Therapy Insights 2025; 11(10), 1267

DOI: 10.18609/cgti.2025.147

Published: 26 November
FastFacts
Alexandre Michaux


 

CAR-T manufacturing relies on high-quality leukapheresis starting material, but manual cryopreservation introduces variability that can impact product consistency. This poster presents data evaluating the IntegriCell™ automated closed cryoprocess (ACP), designed to standardize leukapheresis cryopreservation while preserving cell viability and phenotype. The ACP workflow supports reproducible, cGMP-compliant processing for autologous and allogeneic CAR-T applications.

This video presentation, accompanied by a poster summary, highlights how cryo-processed leukapheresis performed in an automated closed system can reliably generate high-quality starting material that supports robust, scalable manufacturing of CAR-T cell therapies.


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